Selection criteria for drug-treated animals in two-kidney, one clip renal hypertension.
نویسندگان
چکیده
منابع مشابه
Two-Kidney, One-Clip Hypertension in the Rat
Baroreflex function was studied in conscious early phase (<6 weeks) two-kidney, one-clip hypertensive rats before and 24 hours after surgical reversal of hypertension by removal of the constricting renal artery clip or after pharmacological reduction of blood pressure by an infusion of hydralazine or captopril. A normotensive sham-clipped group was included. Another group of two-kidney, one-cli...
متن کاملRenal atrial peptide receptors and natriuresis in two-kidney, one clip hypertension.
It has been suggested that the impaired natriuretic response of the clipped kidney in two-kidney, one clip hypertensive rats is related to downregulation of renal atrial natriuretic peptide receptors. To test this hypothesis, blood volume expansion and atrial peptide binding studies were performed in this model. Infusion of 1% and then 1.5% body weight donor blood (n = 6) caused a progressive i...
متن کاملRenal expression of aminopeptidase A in rats with two-kidney, one-clip hypertension.
BACKGROUND Angiotensin II (ANG II) is a major factor involved in the progression of chronic renal disease. Although the generation of this vasoactive peptide has been investigated in great detail, only a few studies have hitherto addressed the metabolism of ANG II into fragments such as angiotensin III and IV (ANG III, IV) which may exert physiological effects independent of ANG II. Aminopeptid...
متن کاملChemical renal medullectomy; effect upon reversal of two-kidney, one-clip hypertension in the rat.
1. Chemical renal medullectomy was produced in rats by injection of 2-bromoethylamine hydrobromide. Plasma creatinine and blood pressure were unchanged although urine volume was increased fourfold. 2. Left renal artery constriction resulted in similar degrees of hypertension in both intact and medullectomized rats. This was associated with a significantly smaller rise in plasma renin concentrat...
متن کاملImportance of the renal nerves in established two-kidney, one clip Goldblatt hypertension.
Increased sympathetic nervous system activity has been demonstrated in established twokidney, one clip hypertension in the rat. To determine the importance of the renal nerves in this model of hypertension, renal denervation of the clipped kidney (n = IS), renal denotation of the nondlpped kidney (n = 14), sham operation (n = 20), or undlpping (n = 12) was carried out 6 weeks after the onset of...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1986
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.8.8.700